Provita Berberine TPGS - Bonus - A well-researched orthomolecular combination of ingredients that provides a significantly higher Berberine coefficient of absorption and utilization. Berberine is an alkaloid present in several plants such as Goldenseal, Oregon grape, Barberry, and Chinese Goldthread. Recent studies of Berberine were carried out establishing clearly that Berberine has a therapeutic use in metabolic syndrome (MSyn) characterized by high blood sugar and A1c levels. Berberine is poorly absorbed across the gut wall and therefore high doses must be taken to achieve therapeutic results. In addition, Berberine is degraded by stomach acids. Berberine TPGS is encapsulated in delay release (DR) capsules to minimize the impact of stomach acids. It also contains a support blend that significantly improves absorption, bio-availability and utilization. Therefore, lower dosages of Berberine are needed but with increased efficacy. This also means less probability for gastrointestinal discomfort.