Natural Factors St. John's Wort - St. John's Wort has proven effective and has become very popular recently as a natural "anti-depressant", used extensively to treat restlessness, anxiety and mild-to-moderate anxiety. It also possesses anti-bacterial and anti-viral properties and has been used topically for centuries, treating burns, bites and other wounds. St. John's Wort should not, however, be taken in conjunction with MAO-Inhibiting drugs such as L-Dopa or 5HTP. Beat the blues with this non-habit-forming, natural relaxant.