Natural Factors PEA400 - A chronic pain relief formula made from fractionated non-GMO safflower seed oil. Palmitoylethanolamide (PEA) is a fatty-acid-like compound found naturally in certain foods and made within the body. Micronization improves PEA’s solubility and absorption to help manage a variety of conditions associated with chronic pain and discomfort. PEA has analgesic, neuroprotective, and anti-neuroinflammatory properties. It activates the endocannabinoid system and has been used successfully for conditions associated with chronic pain and discomfort. It has been studied for nerve compression syndromes, including sciatica and carpal tunnel syndrome, and for pain caused by pinched nerves and temporomandibular joint (TMJ) disorders.